President Biden Paxlovid Rebound and Update

In this video, Roger Seheult, MD of MedCram explains how Paxlovid can be associated with a “rebound” COVID-19 infection as recently occurred with President Biden.  He first tested positive on July 21 for COVID-19 with symptoms of a runny nose, fever, and cough. He received a 5 day Paxlovid course (MedCram video), but subsequently tested positive again for COVID-19 on July 30th after he had already tested negative. President Biden has had 2 doses of the Pfizer vaccine and received two additional boosters. He was relatively asymptomatic with his “rebound” case. 

Paxlovid

The original study on Paxlovid by Pfizer was done in individuals who never were vaccinated. So the question really is how worthwhile is it for vaccinated individuals to take Paxlovid? Would it help in President Biden’s case? Pfizer did start a study on using Paxlovid in vaccinated individuals; however the endpoint of progression to hospitalization was so low that it did not show any statistical significance and Pfizer ended up stopping the study early. 

Rebound COVID-19

So what needs to be done if you develop a rebound COVID-19 case after taking Paxlovid? Per the CDC, no additional treatment is needed. You can review those guidelines here.

Update on current status of pandemic

As for the pandemic that is currently still ongoing per Dr. Seheult, at least in Riverside and San Bernardino counties, the tracker shows that cases and hospitalizations are on the rise. The caveat being that in terms of cases, due to overall less testing being done, the numbers are probably underestimated. With hospitalizations, it must be noted that everyone who is admitted to the hospital gets a COVID-19 test. Many that are admitted are found to be positive for COVID-19 but do not have any respiratory symptoms. They have been admitted for other diagnosis but found to be concomitantly positive with COVID-19.  

Should I still get vaccinated or boosted?

If you are interested in whether it’s worth still getting a vaccination, the NY State Covid-19 Breakthrough data has looked at data from the beginning of the pandemic. Overall, when comparing vaccinated persons vs. unvaccinated persons, there is still an eightfold increase in hospitalizations in those that are unvaccinated. For more information on COVID-19 and other diseases please be sure to visit us at MedCram.com

LINKS / REFERENCES:

Pfizer COVID 19 FDA Authorized Pill “Paxlovid” Explained (MedCram) | https://youtu.be/GMMTw0MAT-8

Pfizer gives up on Paxlovid in less vulnerable COVID patients after data fail to impress (Fierce Pharma) | https://www.fiercepharma.com/pharma/p…

Biden Tests Positive for Coronavirus Again in ‘Rebound’ Case (NYT) | https://www.nytimes.com/2022/07/30/us…

COVID-19 Response (San Bernardino County) | https://covid19-sbcph.hub.arcgis.com

COVID-19 Breakthrough Data (New York State) | https://coronavirus.health.ny.gov/cov…

COVID-19 Rebound After Paxlovid Treatment (CDC) | https://emergency.cdc.gov/han/2022/pd…

Biden Tests Positive for COVID-19, Returns to Isolation (US News) | https://www.usnews.com/news/health-ne…

Biden still testing positive after rebound Covid-19 case but ‘continues to feel well,’ White House says (CNN) | https://www.cnn.com/2022/07/31/politi…

 

All coronavirus updates are at MedCram.com (including more discussion on delta variant covid, COVID Delta, COVID children, natural immunity COVID 19, and more).

 

MedCram Update 46: https://youtu.be/EFRwnhfWXxo

MedCram Update 47: https://youtu.be/H1LHgyfPPQ8

MedCram Update 132: https://youtu.be/9OZZ6_M4OB0

Stay Tuned for More Updates 

Our COVID-19 videos are always available for free (and ad-free) at MedCram.com. In addition, check out our full library of courses and lectures on subjects ranging from Hypertension Explained Clearly to Sleep Apnea Explained Clearly Course and many more!

Meanwhile, you can find all of our COVID-19 videos compiled here.

Visit MedCram.com for updates on Monkeypox virus infectious disease and more.

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