{"id":1103,"date":"2022-01-29T17:08:15","date_gmt":"2022-01-30T00:08:15","guid":{"rendered":"https:\/\/blog.medcram.com\/?p=1103"},"modified":"2022-03-14T17:18:21","modified_gmt":"2022-03-15T00:18:21","slug":"monoclonal-antibodies-for-covid-19-update-eua-revoked-148","status":"publish","type":"post","link":"https:\/\/blog.medcram.com\/covid-19\/monoclonal-antibodies-for-covid-19-update-eua-revoked-148\/","title":{"rendered":"Monoclonal Antibodies for COVID-19 Update: EUA Revoked"},"content":{"rendered":"<p style=\"text-align: center;\"><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/GUDx4On1zRo\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<h2><b>Monoclonal Antibodies for COVID 19 Update: EUA Revoked<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">In this <\/span><a href=\"https:\/\/youtu.be\/GUDx4On1zRo\"><span style=\"font-weight: 400;\">148th<\/span><\/a><span style=\"font-weight: 400;\"> update video, Roger Seheult, MD of MedCram discusses the FDA decision to limit emergency use authorization (EUA) for some monoclonal antibody interventions in the presence of the Omicron variant. There are currently 3 monoclonal antibody infusions that have previously been given emergency authorization for use by the FDA from Lilly, Regeneron and GSK for use in reducing hospitalization and severe illness related to COVID-19 infection.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The doctor then explains how monoclonal antibodies work by binding to the spike protein of the virus, thereby neutralizing the virus and rendering it unable to attach to the ACE-2 receptors of the cell. He notes that due to changes in the spike protein of the virus, such as in a variant like Omicron, the monoclonal antibodies may not be able to bind and lose efficacy in neutralizing the Omicron variant.\u00a0 See this MedCram <\/span><a href=\"https:\/\/www.youtube.com\/watch?v=HnFjVXmiglk\"><span style=\"font-weight: 400;\">video<\/span><\/a><span style=\"font-weight: 400;\"> on Monoclonal Antibodies: Omicron Update for more information.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Due to the recent surge of the Omicron variant, testing has been done on the effectiveness of the monoclonal antibodies in vitro using a <\/span><a href=\"https:\/\/www.news-medical.net\/health\/What-is-a-Pseudovirus.aspx\"><span style=\"font-weight: 400;\">pseudovirus<\/span><\/a><span style=\"font-weight: 400;\"> to determine how effective each of the three monoclonal antibodies are at limiting the virus&#8217;s ability to infect based on the variant.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This research has found that the monoclonal antibody infusions from both Lilly and Regeneron have no significant efficacy against the Omicron variant, whereas the GSK infusion does neutralize the Omicron variant. He then analyzes the FDA decision to limit the emergency use authorization (EUA) for Lilly and Regeneron while allowing GSK to maintain its EUA for sotrovimab, the only monoclonal antibody that has been shown to still be effective against the Omicron variant.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For more information on the topics covered in this video, please see the following links and references:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">LINKS \/ REFERENCES:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rates of laboratory-confirmed COVID-19 hospitalizations by vaccination status (CDC) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbl8yOUJsY2ZFTlA3bDJxLVh1Z2Z3cHdpRXo5d3xBQ3Jtc0tuRGVMWWJZSHlWYjBIUjUtdUJmemZjWWxYaGZzM0tuWkJwNWFrNGN3eFdyelRUdWtzN2x0R3BrOTFYaTZpQkpLVE9ZX1daWktRQkN0dWJQZUdCbzJjaTNGS21TYnlwOVQ5NGRSTWRqSUJlU2Q0dDhCRQ&amp;q=https%3A%2F%2Fcovid.cdc.gov%2Fcovid-data-tracker%2F%23covidnet-hospitalizations-vaccination\"> <span style=\"font-weight: 400;\">https:\/\/covid.cdc.gov\/covid-data-trac&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Eric Topol (Twitter) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbkxNMDRJeE9ma00wUFI4SXlQMjhKNm5BS0FCd3xBQ3Jtc0tsQ1c4V05OSERVMTQ3em5QZTJkZWNUMjhaWmg3ZmR2YnluT3kwOXp6Zm1pTkNqOC1EeTZya0JtSFF2cHdJODFpTlZibWNXM0w1Wmw0OGFrdXN0S2xGTHFYa20tMW9oTGlNRzFKUW0tM1R0WUE5VkVCUQ&amp;q=https%3A%2F%2Ftwitter.com%2FEricTopol%2Fstatus%2F1424010346377875457%3Fs%3D20\"> <span style=\"font-weight: 400;\">https:\/\/twitter.com\/EricTopol\/status\/&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Trends in Number of COVID-19 Cases and Deaths in the US Reported to CDC, by State\/Territory (CDC) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqa0NDUFZXeGd0a1BNeTc0ZE5Qc2FITlZjUDRKQXxBQ3Jtc0tubG9kNmpVUVNfOEdFcDhYSjFJb1V6U3JvZlhiSnlzR081TFZ0dWFQZlJHSDZudS1lWTltbFpJRUJZdTF4dnJXeldYS3YyY0NNZmxNTFVZUDhrYmhucWt3LTFoczlvaS1tbUh2N3hiUXRLcUE5ZHR5MA&amp;q=https%3A%2F%2Fcovid.cdc.gov%2Fcovid-data-tracker%2F%23covidnet-hospitalizations-vaccination\"> <span style=\"font-weight: 400;\">https:\/\/covid.cdc.gov\/covid-data-trac&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">COVID Data Tracker (CDC) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbDFjVTVpanhTQXRSbzI1WjZ2UGw5Z2Vud2R2Z3xBQ3Jtc0tsdTB4OHZZcnB4UUFBQUtGNXd4NGYxRV9uZXBGZkhfbWd3N2h5YmFHTjNNVWI2b3liSzhuY0tUcFZfQmRvREFyOG16cGdYcTl2azdKRHNiOEExckJtbjh0cjAwN0ZLOVpTM2NMcGJ3WUpJYUxOM2JiYw&amp;q=https%3A%2F%2Fcovid.cdc.gov%2Fcovid-data-tracker%2F%23variant-proportions\"> <span style=\"font-weight: 400;\">https:\/\/covid.cdc.gov\/covid-data-trac&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Emergency Use Authorization 094 (FDA) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbDRic1praXR0T3FrUEFSLVdNYmc0UDc4SEFRUXxBQ3Jtc0tsZXhCYXJQZU5JcngybUhpVi1YQ2hBdWVnRFViMDgzcG1yNFRUb095RkZWV0lrQ3ZEUnNoZU1YUl9jaUg0ZlNkNkdpX0EyeFdJUFZlemJkT1JvdmFLZjdvdGk1MG1haDJ3OVRzbENYaXFUeVRxbTIzNA&amp;q=http%3A%2F%2Fpi.lilly.com%2Feua%2Fbam-and-ete-eua-fda-authorization-letter.pdf\"> <span style=\"font-weight: 400;\">http:\/\/pi.lilly.com\/eua\/bam-and-ete-e&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">What is a Pseudovirus? (News Medical) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbFhaSWNjY3JtSzd4SUppRG1LMEI3c1lENkQxZ3xBQ3Jtc0tsWl9xY1lWdHVHTlY1cUhfRUdsa1E3NnNNVUJPYmdHallvSmV2aU84T0I2MG5iWVoyQlc1LWxVYmNQTU9SV19YUUUxVG1PdGJ4NV9MMlVzWEtNLWFEZ19BTHA4bVVkTzQ2SjdNa01LZjg3QmE4NlJHUQ&amp;q=https%3A%2F%2Fwww.news-medical.net%2Fhealth%2FWhat-is-a-Pseudovirus.aspx\"> <span style=\"font-weight: 400;\">https:\/\/www.news-medical.net\/health\/W&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">B.1.1.529 escapes the majority of SARS-CoV-2 neutralizing antibodies of diverse epitopes (bioRxiv) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbVdLNl9OZU5ySUxhVTgyMENacUdNN2VWZE5uUXxBQ3Jtc0trSnJaVG1LeXJVM2JCV1lFV05fRXFxZ1pYZm8wckI0bmF1ZFU1OEE1SVFoRUNGSlh3NjNTWUltcG5BOTZQeUNqbHB2X1ZUa083dFA0NmN3MklKMDEzaFNwQ3hldEVxaldreGVFNXo1aWluZWN5QTd3MA&amp;q=https%3A%2F%2Fwww.biorxiv.org%2Fcontent%2F10.1101%2F2021.12.07.470392v1.full.pdf\"> <span style=\"font-weight: 400;\">https:\/\/www.biorxiv.org\/content\/10.11&#8230;<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n<h2><b>Stay Tuned for More COVID-19 Updates\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Our COVID-19 videos are always available for <\/span><i><span style=\"font-weight: 400;\">free <\/span><\/i><span style=\"font-weight: 400;\">(and ad-free) at<\/span><a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\"> <span style=\"font-weight: 400;\">MedCram.com<\/span><\/a><span style=\"font-weight: 400;\">. In addition, check out our full library of courses and lectures on subjects ranging from<\/span> <a href=\"https:\/\/www.medcram.com\/courses\/medcram-reviews-hematology\"><span style=\"font-weight: 400;\">Hematology MedCram Reviews<\/span><\/a><span style=\"font-weight: 400;\"> to<\/span> <a href=\"https:\/\/www.medcram.com\/courses\/influenza-explained-clearly\"><span style=\"font-weight: 400;\">Influenza Explained Clearly<\/span><\/a><span style=\"font-weight: 400;\"> course and many more!<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Meanwhile, you can find all of our COVID-19 videos compiled <\/span><a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\"><span style=\"font-weight: 400;\">here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>Monoclonal Antibodies for COVID 19 Update: EUA Revoked In this 148th update video, Roger Seheult, MD of MedCram discusses the FDA decision to limit emergency use authorization (EUA) for some monoclonal antibody interventions in the presence of the Omicron variant. There are currently 3 monoclonal antibody infusions that have previously been given emergency authorization for&hellip;<!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":8,"featured_media":1104,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25,16],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Monoclonal Antibodies for COVID-19 Update: EUA Revoked - Medcram Blog<\/title>\n<meta name=\"description\" content=\"In this 148th update video, Roger Seheult, MD of MedCram discusses the FDA decision to limit emergency use authorization (EUA) for some monoclonal antibody interventions in the presence of the Omicron variant.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.medcram.com\/covid-19\/monoclonal-antibodies-for-covid-19-update-eua-revoked-148\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Monoclonal Antibodies for COVID-19 Update: EUA Revoked - 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