{"id":1144,"date":"2022-03-30T12:57:59","date_gmt":"2022-03-30T19:57:59","guid":{"rendered":"https:\/\/blog.medcram.com\/?p=1144"},"modified":"2022-04-11T13:12:10","modified_gmt":"2022-04-11T20:12:10","slug":"recognize-and-treat-chemical-weapons-sarin-gas","status":"publish","type":"post","link":"https:\/\/blog.medcram.com\/uncategorized\/recognize-and-treat-chemical-weapons-sarin-gas\/","title":{"rendered":"Recognize and Treat Chemical Weapons: Sarin Gas"},"content":{"rendered":"<p style=\"text-align: center;\"><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/FILU9EUEJz4\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><span style=\"font-weight: 400;\">In this video, Roger Seheult, MD of MedCram discusses chemical weapons and their effects on the human body and how to treat them if you are medical personnel in the field. He discusses sarin gas specifically.\u00a0 This was used in the last 20-30 years in warfare. Sarin gas was used in Tokyo, Japan in 1995 and in Syria in 2013 where it was used to kill between 300-1700 people.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-weight: 400;\">Nervous system transmission or passage of signals<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Nerves normally interact with each at synapses. Transmission of information occurs in the body in the synaptic cleft (space between the synapse). When an electrical impulse comes down a nerve, it triggers the release of a compound called acetylcholine into the synaptic cleft. On the postsynaptic neuron are receptors that bind the acetylcholine and cause a stimulation allowing for continued transmission of the electric signal.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This signal will eventually terminate in either an organ or muscle to cause the desired action. For example, in a muscle, it will cause contraction. In the mouth, saliva may be secreted.\u00a0 Dr. Seheult shows a table of the different effects of an electrical impulse and how it results in reactions in the parasympathetic and sympathetic systems.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-weight: 400;\">Nervous system termination or stopping of signals<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The body also needs to be able to break down the acetylcholine to prevent ongoing stimulation of the end organ target. There is an enzyme called acetylcholinesterase that breaks acetylcholine down. Then the individual molecules are reabsorbed to be reformed into acetylcholine. This allows for the impulses to be turned off or on quickly.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-weight: 400;\">How sarin gas works<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u00a0Sarin gas affects nerve transmission. It prevents acetylcholinesterase from doing its job by blocking its ability to break down acetylcholine. This results in an elevated concentration in the synaptic cleft of acetylcholine. As a result, there is an overstimulation of the nerve. Furthermore, because there is nothing to break down the acetylcholine there is no termination of the signal.\u00a0 So the end organs get overstimulated.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-weight: 400;\">Sarin gas toxicity<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Sarin gas is odorless and colorless. Signs of sarin gas toxicity include convulsions, excessive saliva, pinpoint pupils, blurred vision, frothing at the mouth, low heart rates, and respiratory distress.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-weight: 400;\">Sarin gas antidotes.\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are two ways to treat patients with sarin gas exposure. One is to administer atropine which stops the ability of acetylcholine to attach to the receptor and helps block transmission.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Another is to use 2 PAM or pralidoxime. This blocks the ability of sarin gas to bind to the acetylcholinesterase receptor. This only works if the sarin gas comes off the receptor. There is evidence that the sarin gas, if not removed early from the receptor can experience something called aging and become bound irreversibly to the receptor.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is important to give both agents as early as possible to get better results and reversal of the sarin gas. Atropine should be administered first. He shows the dosing for both agents. 2PAM must be given as an infusion. These are the <\/span><a href=\"https:\/\/www.atsdr.cdc.gov\/csem\/cholinesterase-inhibitors\/pralidoxime.html\"><span style=\"font-weight: 400;\">CDC recommendations<\/span><\/a><span style=\"font-weight: 400;\"> for this. For medical personnel, it is important to know the biochemistry and pharmacology of these drugs especially if you are treating individuals with this.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">LINKS \/ REFERENCES:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">M55 (Wikipedia) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbGcyQ2tPdU5CQklSYlhmblR3OFhFd08tb0hBUXxBQ3Jtc0ttalFFeFVsM2ozYW9fQzVCbFpCaUt0SzRCT2xzNGxrOVRtd3E5LUpWMVA4b29RYjFEMEZXamk2RGg1QXhEU2hnUDNibnVVM0cxeG9zaVpuajFKTUVOa2UyVUhKRU1yNEJhM0IxX01vX3VWY3o5X3FtYw&amp;q=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FM55_%28rocket\"> <span style=\"font-weight: 400;\">https:\/\/en.wikipedia.org\/wiki\/M55_(ro&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Ghouta chemical attack (Wikipedia) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbnNFZml6Y0VlaEpLekpjaXYwcDB4Q3Z1SzZ3UXxBQ3Jtc0tsRVJZQjlXSjFLMk94Z3hJZFhDb2c5NjVqRzRyQU1oNm1Yc2FCZHdYQUxoWHVVQk9EdTVaU3NIMV92dlZBRjQ1N2JkUEhPeGM3dEJ2dUtSWU5HM0FYQmx0dzNPNW1nUjBJd2xOSjFyWkJ3Y3ktMVBkOA&amp;q=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FGhouta_chemical_attack%23Witness_statements_and_victim_symptoms\"> <span style=\"font-weight: 400;\">https:\/\/en.wikipedia.org\/wiki\/Ghouta_&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">The Autonomic Nervous System (Wikipedia) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbEZIYXBkRHlTOHpVbkY0ZFl2S256clJ1RXozQXxBQ3Jtc0trWTFQZDYyUHZKRktpZzJBQmxYSGkwdlFZMTgzbWIxdW43RmFaRXFLZFNmLWtnd1VZbW9tZ1dLT2tsQjMxZU81ZDBaam5KSFpFZVViclpRaHpneHcwREMxX3hRX3BxUXp5ZURHcjh3eDdHVllhVWsxWQ&amp;q=https%3A%2F%2Fupload.wikimedia.org%2Fwikipedia%2Fcommons%2Fc%2Fc5%2FThe_Autonomic_Nervous_System.jpg\"> <span style=\"font-weight: 400;\">https:\/\/upload.wikimedia.org\/wikipedi&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Cholinesterase Inhibitors: Including Pesticides and Chemical Warfare Nerve Agents (ATSDR) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqa1RTTzJGS184bl9xd2ZLOFlMTTRCM0hCa1kxUXxBQ3Jtc0tuSklPRjJLamNnejV2ZHZHREg4SVBfN0VGLVNLQlY4dzh1RkUzS1hQNW5lWHJyTF9xa2lwdy1tT1NzUnVPaVZFd2tQeW9ZSlR1b2gzREl5UkNtNVFlNUlHNUc2ekFyUGRnZHJYTkVKek9iZVlzbm1SVQ&amp;q=https%3A%2F%2Fwww.atsdr.cdc.gov%2Fcsem%2Fcholinesterase%2Fdocs%2Fcholinesterase.pdf\"> <span style=\"font-weight: 400;\">https:\/\/www.atsdr.cdc.gov\/csem\/cholin&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Pralidoxime (ATSDR) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbThKSjlPTWJDVk1VZzd0RUhaaE1sVUVpZE1fd3xBQ3Jtc0tuN2NJMDlTdVMxU2IzTmhQeC10bFp2LWo1aUNMQUt5Y3FIXzhfSWFvbGhaYVowN2wyVGJVdU80MzNNdmIwOFdGd2FVNEFpWTZfVVVZVWE4eWtyN0xyOWliMVVxeXMtbm1SUTg4bnYwemRleW1fZ2VEOA&amp;q=https%3A%2F%2Fwww.atsdr.cdc.gov%2Fcsem%2Fcholinesterase-inhibitors%2Fpralidoxime.html\"> <span style=\"font-weight: 400;\">https:\/\/www.atsdr.cdc.gov\/csem\/cholin&#8230;<\/span><\/a><\/p>\n<p><b>Stay Tuned for More COVID-19 Updates\u00a0<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Our COVID-19 videos are always available for <\/span><i><span style=\"font-weight: 400;\">free <\/span><\/i><span style=\"font-weight: 400;\">(and ad-free) at<\/span><a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\"> <span style=\"font-weight: 400;\">MedCram.com<\/span><\/a><span style=\"font-weight: 400;\">. In addition, check out our full library of courses and lectures on subjects ranging from<\/span> <a href=\"https:\/\/www.medcram.com\/courses\/hypertension-explained-clearly-2\"><span style=\"font-weight: 400;\">Hypertension Explained Clearly<\/span><\/a><span style=\"font-weight: 400;\"> to<\/span><a href=\"https:\/\/www.medcram.com\/courses\/sleep-apnea-explained-clearly\"> <span style=\"font-weight: 400;\">Sleep Apnea Explained Clearly<\/span><\/a><span style=\"font-weight: 400;\"> Course and many more!<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Meanwhile, you can find all of our COVID-19 videos compiled <\/span><a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\"><span style=\"font-weight: 400;\">here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>In this video, Roger Seheult, MD of MedCram discusses chemical weapons and their effects on the human body and how to treat them if you are medical personnel in the field. He discusses sarin gas specifically.\u00a0 This was used in the last 20-30 years in warfare. Sarin gas was used in Tokyo, Japan in 1995&hellip;<!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":8,"featured_media":1146,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Recognize and Treat Chemical Weapons: Sarin Gas - Medcram Blog<\/title>\n<meta name=\"description\" content=\"In this video, Roger Seheult, MD of MedCram discusses chemical weapons (sarin gas) and the effects on the human body and how to treat it if you are medical personnel in the field.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.medcram.com\/uncategorized\/recognize-and-treat-chemical-weapons-sarin-gas\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Recognize and Treat Chemical Weapons: Sarin Gas - 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