{"id":1211,"date":"2022-06-03T17:23:48","date_gmt":"2022-06-04T00:23:48","guid":{"rendered":"https:\/\/blog.medcram.com\/?p=1211"},"modified":"2022-06-03T17:23:48","modified_gmt":"2022-06-04T00:23:48","slug":"medcram-recent-study-cell-compares-4-vaccines-natural-infection-covid-19","status":"publish","type":"post","link":"https:\/\/blog.medcram.com\/covid-19\/medcram-recent-study-cell-compares-4-vaccines-natural-infection-covid-19\/","title":{"rendered":"Covid 19 comparision: Pfizer vs Moderna vs Natural Infection vs Novavax vs Johnson and Johnson"},"content":{"rendered":"<p style=\"text-align: center;\"><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/LBXdVhbFuLU\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><span style=\"font-weight: 400;\">In this video, Roger Seheult, MD of MedCram explains a recent <\/span><a href=\"https:\/\/www.cell.com\/cell\/pdf\/S0092-8674%2822%2900653-5.pdf\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> out of the prestigious science journal<\/span><i><span style=\"font-weight: 400;\"> Cell <\/span><\/i><span style=\"font-weight: 400;\">that compares all four available COVID-19 vaccines in the U.S. (Moderna, Pfizer, Novavax, Johnson &amp; Johnson) versus natural COVID-19 infection and the efficacy after 6 months. The principal investigators include Dr. Weiskopf, Dr. Crotty, and Dr. Sette.\u00a0 They review the binding immunoglobulins (IgG), neutralization of the virus, CD4 cells, circulating T follicular helper cell,\u00a0 CD8 cells, and memory B cells in comparison across the vaccines and in natural infection concluding at 6 months.\u00a0 <\/span><\/p>\n<h2>Purpose of the Study<\/h2>\n<p><span style=\"font-weight: 400;\">The purpose of this study is not to say which vaccine is better. Vaccines in general and more specifically each type of vaccine (ie mRNA, adenovirus vector versus traditional) each carry their own benefit and risk. The purpose of this study was to look from an immunological standpoint and see what the effects on the immune system were with each type of vaccine and natural infection. It was to look at the benefits and efficacy of each of the vaccines and natural infection to protect against infection and disease in SARS-CoV-2.\u00a0 <\/span><\/p>\n<h2>Limitations of the Study<\/h2>\n<p><span style=\"font-weight: 400;\">Limitations of this study include that it only addressed the native SARS-CoV-2 virus and not the subsequent variants. Also, other vaccines such as Astra Zeneca, Coronavac, Sinopharm, and Sputnik were not included due to lack of availability.\u00a0<\/span><\/p>\n<h2>Study Findings<\/h2>\n<p><span style=\"font-weight: 400;\">The study found that antibodies against the spike protein IgG at 6 months were seen in all the vaccines and in naturally infected individuals. It concluded that recipients of mRNA vaccines had a 4.5-fold higher spike IgG, 6.4-fold higher RBD IgG, and a 3.40-fold higher neutralizing antibody titer compared to natural infection. Antibody titers from the Novovax recipients also trended higher than SARS-CoV-2 infected subjects. Antibody titers from the Johnson and Johnson were similar to titers from SARS-CoV-2 infected subjects.\u00a0\u00a0<\/span><\/p>\n<h2>Immunity and Antibody Response<\/h2>\n<p><span style=\"font-weight: 400;\">However, immunity is more than just the antibody response when it comes to staying out of the hospital and maintaining wellness.\u00a0 If you can elicit a T cell response you can get a more robust cell-mediated immunity.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Conclusion\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The study found overall that while antibody levels decline, memory T cells and B cells were comparatively stable.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">LINKS \/ REFERENCES:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Humoral and cellular immune memory to four COVID-19 vaccines (Cell) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqa3ZGQVFIMmpMdEdfNEVhVVVlWXctd0hHYUxyQXxBQ3Jtc0trNVJsYUJ3eTZmakVoUHRnRXlwWW8tUUFId1pCdzA3dE1MU3pmVF8tS0hXc1dLd1d2RVotZ3loTmwzb1VxcGpKNXdfbEM5SVRMVnl3bVpvd2FmeEtSaGFiczZKZzhCcDYxcUEyXzBjc002OEw4QlJwVQ&amp;q=https%3A%2F%2Fwww.cell.com%2Fcell%2Fpdf%2FS0092-8674%2822%2900653-5.pdf&amp;v=LBXdVhbFuLU\"> <span style=\"font-weight: 400;\">https:\/\/www.cell.com\/cell\/pdf\/S0092-8&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells (Science) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqa2hodkwzSnNXcmxBNU1XSWc2bE80c1BTc29Kd3xBQ3Jtc0tsUHZlenhZWHFpel9VeVJGVHpQMWg2MnVSOVd0Q0oyem9EcVdKYy1HNGNrZEdYV09mQW9ROHBRemttSzZwMlhyLWdBYkpGSU1SbVI1WjVjTzYxZHBBVjRXWjRYSC1wbW8ya0dYaDhydC1nM1Zzc3dqYw&amp;q=https%3A%2F%2Fwww.science.org%2Fdoi%2F10.1126%2Fscience.abj9853&amp;v=LBXdVhbFuLU\"> <span style=\"font-weight: 400;\">https:\/\/www.science.org\/doi\/10.1126\/s&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">MedCram Update 46:<\/span><a href=\"https:\/\/www.youtube.com\/watch?v=EFRwnhfWXxo&amp;t=0s\"> <span style=\"font-weight: 400;\">https:\/\/youtu.be\/EFRwnhfWXxo<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">MedCram Update 47:<\/span><a href=\"https:\/\/www.youtube.com\/watch?v=H1LHgyfPPQ8&amp;t=0s\"> <span style=\"font-weight: 400;\">https:\/\/youtu.be\/H1LHgyfPPQ8<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">MedCram Update 132:<\/span><a href=\"https:\/\/www.youtube.com\/watch?v=9OZZ6_M4OB0&amp;t=0s\"> <span style=\"font-weight: 400;\">https:\/\/youtu.be\/9OZZ6_M4OB0<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n<h2><b>Stay Tuned for More Updates\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">All coronavirus updates are at <a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\">MedCram.com<\/a>\u00a0(including more discussion on Novavax, Johnson and Johnson vaccine efficacy, natural immunity COVID 19, and more).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Our COVID-19 videos are always available for <\/span><i><span style=\"font-weight: 400;\">free <\/span><\/i><span style=\"font-weight: 400;\">(and ad-free) at<\/span><a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\"> <span style=\"font-weight: 400;\">MedCram.com<\/span><\/a><span style=\"font-weight: 400;\">. In addition, check out our full library of courses and lectures on subjects ranging from<\/span> <a href=\"https:\/\/www.medcram.com\/courses\/hypertension-explained-clearly-2\"><span style=\"font-weight: 400;\">Hypertension Explained Clearly<\/span><\/a><span style=\"font-weight: 400;\"> to<\/span><a href=\"https:\/\/www.medcram.com\/courses\/sleep-apnea-explained-clearly\"> <span style=\"font-weight: 400;\">Sleep Apnea Explained Clearly<\/span><\/a><span style=\"font-weight: 400;\"> course and many more!<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Meanwhile, you can find all of our COVID-19 videos compiled <\/span><a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\"><span style=\"font-weight: 400;\">here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Visit <\/span><a href=\"https:\/\/www.medcram.com\/\"><span style=\"font-weight: 400;\">MedCram.com<\/span><\/a><span style=\"font-weight: 400;\"> for updates on Monkeypox virus infectious disease and more.<\/span><\/p>\n<p>&nbsp;<\/p>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>In this video, Roger Seheult, MD of MedCram explains a recent study out of the prestigious science journal Cell that compares all four available COVID-19 vaccines in the U.S. (Moderna, Pfizer, Novavax, Johnson &amp; Johnson) versus natural COVID-19 infection and the efficacy after 6 months. The principal investigators include Dr. Weiskopf, Dr. Crotty, and Dr.&hellip;<!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":8,"featured_media":1212,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Covid 19 comparision: Pfizer vs Moderna vs Natural Infection vs Novavax vs Johnson and Johnson - Medcram Blog<\/title>\n<meta name=\"description\" content=\"In this video, Roger Seheult, MD of MedCram explains a recent study out of the prestigious science journal Cell that compares all four available COVID-19 vaccines in the U.S. (Moderna, Pfizer, Novavax, Johnson &amp; Johnson) versus natural COVID-19 infection and the efficacy after 6 months.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.medcram.com\/covid-19\/medcram-recent-study-cell-compares-4-vaccines-natural-infection-covid-19\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Covid 19 comparision: Pfizer vs Moderna vs Natural Infection vs Novavax vs Johnson and Johnson - 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