{"id":1295,"date":"2022-08-08T18:22:47","date_gmt":"2022-08-09T01:22:47","guid":{"rendered":"https:\/\/blog.medcram.com\/?p=1295"},"modified":"2022-08-12T18:46:32","modified_gmt":"2022-08-13T01:46:32","slug":"sars-cov2-spike-protein-expression-in-mice-causes-damage-via-innate-immune-system-update-158","status":"publish","type":"post","link":"https:\/\/blog.medcram.com\/covid-19\/sars-cov2-spike-protein-expression-in-mice-causes-damage-via-innate-immune-system-update-158\/","title":{"rendered":"SARS-CoV2 Spike Protein Expression in Mice Causes Damage via Innate Immune System Update 158"},"content":{"rendered":"<p style=\"text-align: center;\"><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/NgiU8q_xf3g\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><span style=\"font-weight: 400;\">I<\/span><span style=\"font-weight: 400;\">n this video, Roger Seheult, MD of MedCram explains a <\/span><a href=\"https:\/\/www.dicardiology.com\/content\/coronavirus-spike-protein-activated-natural-immune-response-damaged-heart-muscle-cells\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> that was presented at the American Heart Association that suggests that the SARS-CoV-2 spike protein is directly toxic to the heart <\/span><span style=\"font-weight: 400;\">without utilizing the ACE2 receptor to cause damage.\u00a0 This study was done in New York and looked at a mouse model.<\/span><\/p>\n<h2>Mouse cells and ACE2 receptor<\/h2>\n<p><span style=\"font-weight: 400;\">The study used mice cells which also have an ACE2 receptor but unlike the human ACE2 receptor, the mouse ACE2 receptor does not interact with SARS-CoV-2.\u00a0 Scientists took a viral vector and for one arm of the study they cloned the SARS-CoV-2 virus spike protein (it was not specified which variant was cloned) and then put it into the viral vector to infect the heart mouse cell. They did this again in the second arm with another coronavirus spike protein that was only associated with a cold or mild respiratory symptoms but was not known to cause any heart issues. Both of these spike proteins used again are capable of interacting with human ACE2 receptors but not mouse ACE2 receptors.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">What was noted in the study was that in the heart mouse cells infected with the SARS-CoV-2 spike protein, there were additional proteins that were found such as the TLR4 (toll like receptor) along with the spike protein. It was noted that there was an increase in inflammation that was occurring along those areas.\u00a0 In the non-SARS-CoV-2 infected mouse heart cell (ie the \u201cregular\u201d coronavirus) it was not noted to have any increase in inflammation.\u00a0\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">SARS-CoV-2 spike protein and ACE2 receptor<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The study implies there is something about the SARS-CoV-2 spike protein after it is created in the cell that causes a reaction and inflammation that has nothing to do with the activation of the ACE2 receptor. Dr. Seheult speculates that it may be a protein or pathogen association pattern that could be triggering the inflammatory response\u00a0 from the immune system that is not related to the ACE2 receptor. It is not clear if this is due to the spike protein itself or other proteins associated with it.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Not everyone who gets SARS-CoV-2 via a natural infection or who has received a vaccine gets heart inflammation. The spike protein that is sequenced and placed in vaccines is significantly different than the spike protein in the SARS-CoV-2. The vaccine spike protein was specifically engineered to stay in the pre-fusion state to keep the spike protein fused in a specific conformation. Jason McLellan <\/span><a href=\"https:\/\/www.youtube.com\/watch?v=EH2QIxmZIWA&amp;t=1324s\"><span style=\"font-weight: 400;\">describes this process<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h2>SARS-CoV-2 and delayed immune response<\/h2>\n<p><span style=\"font-weight: 400;\">To get inflammation in the heart cells requires for the virus to get into them to cause inflammation.\u00a0 <\/span><span style=\"font-weight: 400;\">It also appears there is something about the SARS-CoV-2 spike protein that delays the immune response that is not found with other coronaviruses. Studies have shown that individuals who have had severe disease with SARS-CoV-2 infections have had a lower interferon response compared to individuals who have had mild to moderate disease which may signify a slower or delayed response with the immune system.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This article hasn\u2019t been yet published but has presented a lot of data. There are still a multiple of\u00a0 unanswered questions that need more research.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">LINKS \/ REFERENCES:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jason McLellan: &#8220;Structure-based Design of Vaccine Antigens for SARS-CoV-2&#8221; (HHMI) |<\/span><a href=\"https:\/\/www.youtube.com\/watch?v=EH2QIxmZIWA&amp;t=1324s\"> <span style=\"font-weight: 400;\">https:\/\/youtu.be\/EH2QIxmZIWA?t=1324<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Coronavirus Spike Protein Activated Natural Immune Response, Damaged Heart Muscle Cells (DAIC) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbk1ZYkZZT1B5ZnNGVk9JWGgwcVVaT3RRUjZKQXxBQ3Jtc0trZ0JiVmF5UnpEUWpaNDFSNjRPcTgtemZrZ2ItejMtWkRneVU1M2VuQTdFdXpMTFNxaFkxaktoX25NbkFWYnZZV0VvNVdxUzV2M3dDR0hlZjVoUzR3eEFwd1BiYVFLTnRzdk85Ty1YQ2I5c2Zwc1VBUQ&amp;q=https%3A%2F%2Fwww.dicardiology.com%2Fcontent%2Fcoronavirus-spike-protein-activated-natural-immune-response-damaged-heart-muscle-cells&amp;v=NgiU8q_xf3g\"> <span style=\"font-weight: 400;\">https:\/\/www.dicardiology.com\/content\/&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy (Hindawi) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbGZldDlXeVFXOUxURldIOFVvWDlLMnRLNldKUXxBQ3Jtc0tuOVJBM3JTSUhiNDhPaXRJV1lGVHU3WEU2V2FaQ1FfenE5NG1WSTRSVmJ5dE5mcFZOUnptUm9PNWxrdGduVUtIZ29DS2xJS09FUVczTHFXSG1mVzZRREpDZC1QYURNMHZUV3VpVmNfUXhzQ196bHRsRQ&amp;q=https%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjir%2F2020%2F2045860%2F&amp;v=NgiU8q_xf3g\"> <span style=\"font-weight: 400;\">https:\/\/www.hindawi.com\/journals\/jir\/&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Development of an Adeno-Associated Virus-Vectored SARS-CoV-2 Vaccine and Its Immunogenicity in Mice (Frontiers) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqay1iY3dxTWtGb0tfZ1l1bXRJdzd0MjJUNldVd3xBQ3Jtc0tudl9DTHpaei05WDBBWnJmYktzYWxBRmFZdndjVDl4TGctQ0duN0hKOHFwOGxGVDg2TEhfanY3cTVDYUFIUHdQcjh4cXZ1NTZTYzdfVkFKaUtVX01CaXFqaFlUSnB6aGJjUUxvaDZUbDNLdDdlVXBLbw&amp;q=https%3A%2F%2Fwww.frontiersin.org%2Farticles%2F10.3389%2Ffcimb.2022.802147%2Ffull&amp;v=NgiU8q_xf3g\"> <span style=\"font-weight: 400;\">https:\/\/www.frontiersin.org\/articles\/&#8230;<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">All coronavirus updates are at MedCram.com (including more discussion on delta variant covid, COVID Delta, COVID children, natural immunity COVID 19, and more).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">MedCram Update 46:<\/span><a href=\"https:\/\/www.youtube.com\/watch?v=EFRwnhfWXxo&amp;t=0s\"> <span style=\"font-weight: 400;\">https:\/\/youtu.be\/EFRwnhfWXxo<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">MedCram Update 47:<\/span><a href=\"https:\/\/www.youtube.com\/watch?v=H1LHgyfPPQ8&amp;t=0s\"> <span style=\"font-weight: 400;\">https:\/\/youtu.be\/H1LHgyfPPQ8<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">MedCram Update 132:<\/span><a href=\"https:\/\/www.youtube.com\/watch?v=9OZZ6_M4OB0&amp;t=0s\"> <span style=\"font-weight: 400;\">https:\/\/youtu.be\/9OZZ6_M4OB0<\/span><\/a><\/p>\n<h2><b>Stay Tuned for More Updates\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Our COVID-19 videos are always available for <\/span><i><span style=\"font-weight: 400;\">free <\/span><\/i><span style=\"font-weight: 400;\">(and ad-free) at<\/span><a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\"> <span style=\"font-weight: 400;\">MedCram.com<\/span><\/a><span style=\"font-weight: 400;\">. In addition, check out our full library of courses and lectures on subjects ranging from<\/span> <a href=\"https:\/\/www.medcram.com\/courses\/hypertension-explained-clearly-2\"><span style=\"font-weight: 400;\">Hypertension Explained Clearly<\/span><\/a><span style=\"font-weight: 400;\"> to<\/span><a href=\"https:\/\/www.medcram.com\/courses\/sleep-apnea-explained-clearly\"> <span style=\"font-weight: 400;\">Sleep Apnea Explained Clearly<\/span><\/a><span style=\"font-weight: 400;\"> Course and many more!<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Meanwhile, you can find all of our COVID-19 videos compiled <\/span><a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\"><span style=\"font-weight: 400;\">here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Visit <\/span><a href=\"https:\/\/www.medcram.com\/\"><span style=\"font-weight: 400;\">MedCram.com<\/span><\/a><span style=\"font-weight: 400;\"> for updates on Monkeypox virus infectious disease and more.<\/span><\/p>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>In this video, Roger Seheult, MD of MedCram explains a study that was presented at the American Heart Association that suggests that the SARS-CoV-2 spike protein is directly toxic to the heart without utilizing the ACE2 receptor to cause damage.\u00a0 This study was done in New York and looked at a mouse model. Mouse cells&hellip;<!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":8,"featured_media":1296,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>SARS-CoV2 Spike Protein Expression in Mice Causes Damage via Innate Immune System Update 158 - Medcram Blog<\/title>\n<meta name=\"description\" content=\"In this video, Roger Seheult, MD of MedCram explains a study that was presented at the American Heart Association that suggests that the SARS-CoV-2 spike protein is directly toxic to the heart without utilizing the ACE2 receptor to cause damage.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.medcram.com\/covid-19\/sars-cov2-spike-protein-expression-in-mice-causes-damage-via-innate-immune-system-update-158\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SARS-CoV2 Spike Protein Expression in Mice Causes Damage via Innate Immune System Update 158 - 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