{"id":1301,"date":"2022-08-14T16:26:37","date_gmt":"2022-08-14T23:26:37","guid":{"rendered":"https:\/\/blog.medcram.com\/?p=1301"},"modified":"2022-08-14T16:38:49","modified_gmt":"2022-08-14T23:38:49","slug":"how-monkeypox-spreads","status":"publish","type":"post","link":"https:\/\/blog.medcram.com\/uncategorized\/how-monkeypox-spreads\/","title":{"rendered":"How Monkeypox spreads"},"content":{"rendered":"<p style=\"text-align: center;\"><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/5R3kx3V1N58\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<h2><span style=\"font-weight: 400;\">Monkeypox spread<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In this video, Dr. Seheult of MedCram provides the latest update on Monkeypox. At the present time, the number of cases have slowly and steadily been climbing every day. Worldwide, over 30,000 people have confirmed cases of Monkeypox.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Who is getting Monkeypox?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In a <\/span><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2207323\"><span style=\"font-weight: 400;\">NEJM article<\/span><\/a><span style=\"font-weight: 400;\">, they reviewed 528 Monkeypox infections across 16 countries and found that 98% of the cases were amongst men who have sex with men and 41% of these patients also had HIV with a median CD4 count of 680. The authors concluded that 95% of the transmission was through sexual contact. However, the authors noted that Monkeypox can be contracted by anyone and is not to be considered as disease of only men who have sex with men. There was a case of a physician in Tel Aviv who contracted it despite being in full protective gear and was thought to have gotten it when removing his gloves.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How is it spread?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In a<\/span><a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2822%2901436-2\/fulltext\"><span style=\"font-weight: 400;\"> Lancet article<\/span><\/a><span style=\"font-weight: 400;\">, it discusses how the virus is being spread. It found that the viral load of the Monkeypox virus within the pustules and lesions themselves was higher than what was found in the pharynx (upper airway) which suggested that spread of the virus is less likely through respiratory spread. This observation along with the location of the lesions (more in the genital areas) is suggestive that close contact during sex is the dominant mode of transmission in the Monkeypox outbreak.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Signs and symptoms of Monkeypox<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Signs of symptoms in the NEJM article included fever, lymph node enlargement (typically regional), lethargy, myalgia, headache, and rash.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Treatment of Monkeypox<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In the NEJM article, 5% of the individuals received a course of treatment with an antiviral called Tecovirimat.\u00a0 Tecovirimat is being used off-label for the treatment of Monkeypox. It was originally made for smallpox infections. This medication affects the protein that is responsible for the virus\u2019 ability to bud off the cell. There actually hasn\u2019t been a randomized trial with this as it would not be ethical to infect people with Monkeypox and prior to the outbreak, the incidence of Monkeypox was low.\u00a0 MedCram is providing a <\/span><a href=\"https:\/\/www.cdc.gov\/poxvirus\/monkeypox\/clinicians\/obtaining-tecovirimat.html\"><span style=\"font-weight: 400;\">link for those clinicians that need to obtain tecovirimat.\u00a0<\/span><\/a><\/p>\n<h2><span style=\"font-weight: 400;\">Monkeypox vaccines?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">What about vaccines? There are none available specifically for Monkeypox, but instead vaccines that were created for smallpox are being utilized.\u00a0 There are two vaccines available ACAM2000 and Jynneos. The first vaccine made, ACAM2000 vaccine, allows the virus to replicate which can lead to possible side effects. The subsequent vaccine Jynneos that was approved later is a replication deficient vaccine meaning the virus can\u2019t replicate and hence has less side effects as compared to ACAM2000.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Are the vaccines available?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">At this time, the US only has 400,000 doses.\u00a0 However, a <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0264410X15008762?via%3Dihub\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> in 2015 found that giving the vaccine intradermally required 5x less material but was still effective. Now a vial that would normally be 1 dose can now do 5 doses which can increase the 400,000 doses to approximately 2 million doses. Eligibility for the vaccine is being given for post-exposure prophylaxis and to lab workers with a high likelihood of exposure. There are vaccine campaigns also occurring in the at risk population of men who have sex with men. The company is also working on trying to make more vaccine.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">LINKS \/ REFERENCES:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nov 3, 2021 ACIP Meeting &#8211; Orthopoxviruses Vaccines (CDC) |<\/span><a href=\"https:\/\/www.youtube.com\/watch?v=4SCUOppgtxE&amp;t=0s\"> <span style=\"font-weight: 400;\">https:\/\/youtu.be\/4SCUOppgtxE<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Monkeypox (Our World in Data) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbjIxTkNISk9aZW9EZmljRjJYOGVPNGRZbWRDd3xBQ3Jtc0tuRDl0cmhmenlkbmtlbTUxb0Ryb2xzd0xDOWpiS3ozYWp6cU12OUlOVmRscFhZc2lsamdKdUUxcV9TeXpCN0NwTWdzbnJjUU55dHlURlVyX1BUMEo4Yktzak8zeVVNYXlhejFvTk9NUndSb3dvOFgyaw&amp;q=https%3A%2F%2Fourworldindata.org%2Fmonkeypox&amp;v=5R3kx3V1N58\"> <span style=\"font-weight: 400;\">https:\/\/ourworldindata.org\/monkeypox<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Monkeypox Tracker (Esri Canada) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbDZzUjN6NTlnNVBqZTV6N0JURFV2SUtLZDg5Z3xBQ3Jtc0ttTlR6T0kySFlyaDFmdk1zbkZCWExpcHh1NHRXYTRqU3lwQXNmeFhLcWg5TkQzUXk4R3BCRmRjakU0R2tLeEtwOUpFZU40cC04emJ4cTB5OS1DTmtpSFl3cjkzQXdvNmttcVlrQ1hSaEhnckRxSlo3MA&amp;q=https%3A%2F%2Fmonkeypox-tracker-esricanada.hub.arcgis.com%2F&amp;v=5R3kx3V1N58\"> <span style=\"font-weight: 400;\">https:\/\/monkeypox-tracker-esricanada&#8230;.<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Monkeypox Virus Infection in Humans across 16 Countries \u2014 April\u2013June 2022 (NEJM) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqa1JMUEpSMzVDOS1LWnpabWVaWnRGQUJ1MkhwUXxBQ3Jtc0ttT3IzSUp3d3ZZZkdaUl9NNVM2M3hkUnZvenp1U1VhUVNnTlJiaHNqbWZ1aWNfVlNaVXVYMVY5SmdxQ1RXQV9vUW5ZcURRUmlzd204dEktcUoweTBhR3d2VU9OTm40SmVlSllQb1JYZXFnZzFmMmZlZw&amp;q=https%3A%2F%2Fwww.nejm.org%2Fdoi%2Ffull%2F10.1056%2FNEJMoa2207323&amp;v=5R3kx3V1N58\"> <span style=\"font-weight: 400;\">https:\/\/www.nejm.org\/doi\/full\/10.1056&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Pathogen Safety Data Sheets: Infectious Substances \u2013 Monkeypox virus (Government of Canada) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbEdhRl9tc3BtM1dKLVFjVWY2T0EwTHZKWlN3d3xBQ3Jtc0tsemRZOHppV3p0NEFCd1hza215anNIVjkzOThQWWhoVXZoQ01IYkVNU1hzdjc5bHBsT3BaZmhaWUNHQzBwZzNqWDhqeVl3Y3VOUkJMaHA2V0FTRnNTWXBqWnRKa0V3WFM4NEdjczhCQ09ETzc1U1pZRQ&amp;q=https%3A%2F%2Fwww.canada.ca%2Fen%2Fpublic-health%2Fservices%2Flaboratory-biosafety-biosecurity%2Fpathogen-safety-data-sheets-risk-assessment%2Fmonkeypox-virus.html&amp;v=5R3kx3V1N58\"> <span style=\"font-weight: 400;\">https:\/\/www.canada.ca\/en\/public-healt&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Medical staff call to be vaccinated against monkeypox after doctor infected (Times of Israel) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbVpIZ1RBTWFOMi1vZ3M5U1JnOHpqZkFTQTgxd3xBQ3Jtc0tsVXlTVlRlWDhQN2lUcnVNNEJZeWZLVEZXTlBNZHdENHV3SmpRVzd1bWE3QUp3ODhkNHJiMHBwWWFuVUQzelhKREk0NnNIMUl3eUlJZkxyU0FFV2psRzJpaE9DX1hJeEJGM1hYRGYxUkwzZVJ1NEktWQ&amp;q=https%3A%2F%2Fwww.timesofisrael.com%2Fmedical-staff-call-to-be-vaccinated-against-monkeypox-after-doctor-infected%2F&amp;v=5R3kx3V1N58\"> <span style=\"font-weight: 400;\">https:\/\/www.timesofisrael.com\/medical&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study (Lancet) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbU1SYjRvZnUzOWZPc1lGMVFFYXh0Y253dW91QXxBQ3Jtc0ttNkRPLXZhMVdxYTEzU25lWXg2cUZ1anJDRDNxQ290a1JCUjhlR3RpUllNaGphZ0Qtakwxb2xRMVVmb3V4SWVBZnNPcnFvSEEzRnhRdERuU3FzWG9VaTZpQWE5a3FqUGJUcWZ3am5hMWh2TXpnd2M2SQ&amp;q=https%3A%2F%2Fwww.thelancet.com%2Fjournals%2Flancet%2Farticle%2FPIIS0140-6736%2822%2901436-2%2Ffulltext&amp;v=5R3kx3V1N58\"> <span style=\"font-weight: 400;\">https:\/\/www.thelancet.com\/journals\/la&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Information for Healthcare Providers on Obtaining and Using TPOXX (Tecovirimat) for Treatment of Monkeypox (CDC) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbDBPUjJDVGZ4b0h2eF90b3dER3U1dnZlVU9jZ3xBQ3Jtc0tuZldKTjBTNV9rUERRZ01mWFFiZjF5RDB1c0tSbF91QjVJVmhlVWpkZjdPNXc5M2tIUnVkVTJ0TWdvOFE1b2QxRG9BZV9UbUZPN3AtY3J1RkpEOEJPa083aWRTVG9rbGhIdVpFei1HU3luWUdoOGtEVQ&amp;q=https%3A%2F%2Fwww.cdc.gov%2Fpoxvirus%2Fmonkeypox%2Fclinicians%2Fobtaining-tecovirimat.html&amp;v=5R3kx3V1N58\"> <span style=\"font-weight: 400;\">https:\/\/www.cdc.gov\/poxvirus\/monkeypo&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-na\u00efve subjects (Science Direct) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqa2ZpQ3hqUkl0V1VTVWFJQ2JyME5DSDJNVDlJQXxBQ3Jtc0tsMW5La1ZYNUs3VlVib0xfOHZVY1hZYUphN3Q3cTBHTXhBd3dkWDRZVzlqUzhSNUNENFNiNGdOVnNEV21temk5Q3JCRElDTHNwMmJ4c05zaWpzWnFlUXdLUXpSUEpLeGJ6bnhVRUowM2NaMldQXzliSQ&amp;q=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS0264410X15008762%3Fvia%253Dihub&amp;v=5R3kx3V1N58\"> <span style=\"font-weight: 400;\">https:\/\/www.sciencedirect.com\/science&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study (Lancet) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbXptcWRmMlJka3NiX25rZmZJT0Zrc255VEdtd3xBQ3Jtc0tuVWtacjhyN3FkU0RoRzA1ZXJ5d2d5azJOUkhGX1huM3FGdnlKMXVMeFl1UHl1TDlZa2hTYmo0S1hzYTYwQ3pud2hDcElhR1Q2TFU2TXhLOW93eHZCdUJlRFVocGI0dWVoN1dsSXZNYi11c2piNjlzNA&amp;q=https%3A%2F%2Fwww.thelancet.com%2Fjournals%2Flancet%2Farticle%2FPIIS0140-6736%2822%2901436-2%2Ffulltext&amp;v=5R3kx3V1N58\"> <span style=\"font-weight: 400;\">https:\/\/www.thelancet.com\/journals\/la&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Monkeypox DNA found in Sacramento wastewater samples (ABC10) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbnJDUmYxVlRyZmZHaGpoSWhQQW04UVo0N3dJUXxBQ3Jtc0tsTjlaM2NjbjR1VW4zYW41dEUxZTNzNlNlVnNjejRPVkJ3WXZ6OUhOTzZJT0tlb09EUUVjLWctTmY4bjZkUE5mZjNZZFhQVG1OSXdiUUFqNDVPb3RzOVhFVDBIbHFyWk5DMjJNV0k2eUJjbzNpMnVOcw&amp;q=https%3A%2F%2Fwww.abc10.com%2Farticle%2Fnews%2Fhealth%2Fmonkeypox%2Fmonkeypox-dna-sacramento-wastewater%2F103-96f1402d-ed5f-4bda-93e9-2dbc5815bad2&amp;v=5R3kx3V1N58\"> <span style=\"font-weight: 400;\">https:\/\/www.abc10.com\/article\/news\/he&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Monkeypox Virus (AABB) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbnVpQ2ZTcTZNT0RqQmVQSjM2cDJ6LTZLcTFpd3xBQ3Jtc0ttQk01a01oUU15QTBnbnRLdUtraUFaSVJqTGZYMEtJU2tfMUV2dHdlTEZ0eXgxN0NBRmlod0xkdVpTYXJrLVVhN3M1OG1uaS1nRDhyOFhfUWZXUXVYN3VUS2FDeDJwV2RIbE1tX3BoM0h1dU5mSHZvVQ&amp;q=https%3A%2F%2Fwww.aabb.org%2Fdocs%2Fdefault-source%2Fdefault-document-library%2Fregulatory%2Feid%2F130s.pdf%3Fsfvrsn%3D652b9f22_2%23%3A%7E%3Atext%3DComplete%2520inactivation%2520of%2520the%2520closely%2Cvaccinia%2520to%2520solvent%252Ddetergent%2520treatment&amp;v=5R3kx3V1N58\"> <span style=\"font-weight: 400;\">https:\/\/www.aabb.org\/docs\/default-sou&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Monkeypox Explained Clearly (MedCram) |<\/span><a href=\"https:\/\/www.youtube.com\/watch?v=lWEj4J9cu7Y&amp;t=0s\"> <span style=\"font-weight: 400;\">https:\/\/youtu.be\/lWEj4J9cu7Y<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Visit MedCram.com for more updates on pox virus infectious disease details including monkeypox uk, monkeypox virus diagnosis, and more.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><b>Stay Tuned for More Updates\u00a0<\/b><\/h2>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Our COVID-19 videos are always available for <\/span><i><span style=\"font-weight: 400;\">free <\/span><\/i><span style=\"font-weight: 400;\">(and ad-free) at<\/span><a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\"> <span style=\"font-weight: 400;\">MedCram.com<\/span><\/a><span style=\"font-weight: 400;\">. In addition, check out our full library of courses and lectures on subjects ranging from<\/span> <a href=\"https:\/\/www.medcram.com\/courses\/hypertension-explained-clearly-2\"><span style=\"font-weight: 400;\">Hypertension Explained Clearly<\/span><\/a><span style=\"font-weight: 400;\"> to<\/span><a href=\"https:\/\/www.medcram.com\/courses\/sleep-apnea-explained-clearly\"> <span style=\"font-weight: 400;\">Sleep Apnea Explained Clearly<\/span><\/a><span style=\"font-weight: 400;\"> Course and many more!<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Meanwhile, you can find all of our COVID-19 videos compiled <\/span><a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\"><span style=\"font-weight: 400;\">here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Visit <\/span><a href=\"https:\/\/www.medcram.com\/\"><span style=\"font-weight: 400;\">MedCram.com<\/span><\/a><span style=\"font-weight: 400;\"> for updates on Monkeypox virus infectious disease and more.<\/span><\/p>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>Monkeypox spread In this video, Dr. Seheult of MedCram provides the latest update on Monkeypox. At the present time, the number of cases have slowly and steadily been climbing every day. Worldwide, over 30,000 people have confirmed cases of Monkeypox.\u00a0 Who is getting Monkeypox? In a NEJM article, they reviewed 528 Monkeypox infections across 16&hellip;<!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":8,"featured_media":1302,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16,22,1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How Monkeypox spreads - Medcram Blog<\/title>\n<meta name=\"description\" content=\"In this video, Dr. Seheult of MedCram provides the latest update on Monkeypox.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.medcram.com\/uncategorized\/how-monkeypox-spreads\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How Monkeypox spreads - 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