{"id":1357,"date":"2022-09-20T13:07:24","date_gmt":"2022-09-20T20:07:24","guid":{"rendered":"https:\/\/blog.medcram.com\/?p=1357"},"modified":"2022-10-23T13:57:06","modified_gmt":"2022-10-23T20:57:06","slug":"new-bivalent-boosters","status":"publish","type":"post","link":"https:\/\/blog.medcram.com\/covid-19\/new-bivalent-boosters\/","title":{"rendered":"Omicron booster clearly explained"},"content":{"rendered":"<p style=\"text-align: center;\"><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/wTyNA5FzfQA\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">In this video, Roger Seheult, MD of MedCram discusses the new bivalent boosters that are currently being offered. These new boosters are called bivalent because they have 2 different mRNAs to code for two different spike proteins because Omicron is so different from the original Wuhan strain of SARS-CoV-2. Whether you should get the vaccine will depend on your individual cases. Medicine is nuanced. This video is here to give you as much information as possible to give you the ability to make an educated and informed decision.\u00a0 <\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Bivalent boosters<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Both Moderna and Pfizer have a bivalent booster that has the Original strain and the Omicron BA.4\/BA.5 strain.\u00a0 <\/span><span style=\"font-weight: 400;\">This bivalent product is only for people who have already gotten the first two shots of the vaccine. This is not a primary series.\u00a0 If an individual has already gotten a booster, then they would need to wait at least 2 months since their last booster.\u00a0 <\/span><span style=\"font-weight: 400;\">With the EUA (emergency use authorization) for the new boosters, the old boosters will be removed.\u00a0 Pfizer\/BioNTech has 15 mcg of the Original strain + 15 mcg of the Omicron BA.4.\/BA.5 strain making a 30 mcg dose. Moderna has a dose of 25 mcg of the Original strain and 25 mcg of the Omicron BA.4.\/BA.5 strain making a 50 mcg dose. The Pfizer booster is approved for ages 12+ and the Moderna booster is approved for ages 18 +.\u00a0 The idea behind the bivalent booster was to see if the booster could be more effective by adding the Omicron BA.4 and BA.5 current circulating strains.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Vaccine effectiveness\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It is known that overtime a vaccine will wane in its effectiveness.\u00a0 A study looked at this with the end points of\u00a0 effectiveness against symptomatic infection, against any infection and against hospitalization. This study took place throughout the world over several weeks and found that effectiveness against hospitalization was not significantly degraded as compared to the effectiveness against symptomatic infection or against any infection.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Are the boosters safe?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As of now there is no human data on the safety of the vaccine with BA.4 and BA.5 other than what was done in the mouse study. There are about 4 out of 4000 nucleotides that are different with the BA.4 and BA.5 compared to the BA.1. There are studies on a BA.1 vaccine in humans. One could assume that the variants are close enough to have similar results; however, it must be noted that without the human studies we can not say that for sure.\u00a0 \u00a0They are currently working on human trials with the new bivalent boosters which should be out in October. In the mice studies, it showed that there was a substantial increase in omicron neutralization response to all omicron variants including the BA.4 and BA.5.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">From NEJM there was an <a href=\"https:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2119451\">article<\/a> on the safety of the vaccines and they found that both the Original and BA.1 vaccines had very similar local and system adverse reactions.\u00a0 These do not include studies with BA.4 and BA.5 as these are forthcoming.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adverse reactions were looked at for 7 days after injection and the most common were pain at injection site and myalgias. The overall incidence of adverse events considered related to the study vaccination was 6% in both booster groups.<\/span><\/p>\n<h2>Should I get the booster?<\/h2>\n<p><span style=\"font-weight: 400;\">Some reasons to get the booster are if you have sick contacts, work in a high risk area, have medical problems, older age,\u00a0 there is better immunity against current variant. Reasons not to get the booster include no sick contact, work in low risk area, healthy, younger age, may have possible post infectious immunity. Currently there is no BA.4 and BA.5 variant\u00a0 specific human neutralizing antibody data. Whether you get the booster or not, it is an individual choice that needs to weigh both the pros and cons.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">LINKS \/ REFERENCES:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">COVID-19 Cases and Deaths by Vaccination Status Dashboard (Texas HHS) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbWZIeXVLeFZIVmdOOVFScEw2cFJsRzZnNmZ2d3xBQ3Jtc0tuYWdHN1ppSlJxbXV5V2l2bW5tcExXRFo2NllkR3p5OWNXSWFESHQ3RHNhazQwMEdsTlJpWkRCRXdoR0ZiM2JOZU9VX3p0Ti1tYUlLOUg1QTB5bV83NEcyUTBKb1BhSnVIcHpnRjZvSm1uSjVsc2lrcw&amp;q=https%3A%2F%2Fwww.dshs.texas.gov%2Fimmunize%2Fcovid19%2Fdata%2Fvaccination-status.aspx&amp;v=wTyNA5FzfQA\"> <span style=\"font-weight: 400;\">https:\/\/www.dshs.texas.gov\/immunize\/c&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Fact check: New COVID-19 boosters were tested in just 8 mice? Should it matter? (CBS17) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbXVjLVdjcTRaa2lDNTZkc0E0YkE4TzhLSi0tZ3xBQ3Jtc0tsR3FjVzZsbDFESVl1YkZGMGNIN3ZRREFOU0tWQlo3RU9UeUJYQWkzekV2My1zbmFieEtEMmpiWVNNT3g0Tm9CaUxMSl8yYnIyOUdrUkxFZFk2Ml9WazNYbFV5QlBNOGlQS256V3FkQ25UOWZjTk0xUQ&amp;q=https%3A%2F%2Fwww.cbs17.com%2Fcommunity%2Fhealth%2Fcoronavirus%2Ffact-check-were-new-covid-19-boosters-tested-in-just-8-mice-should-it-matter%2F&amp;v=wTyNA5FzfQA\"> <span style=\"font-weight: 400;\">https:\/\/www.cbs17.com\/community\/healt&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Pfizer\/BioNTech COVID-19 Omicron-Modified Bivalent Vaccine (CDC) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbWpPMUV2XzU4UHM1azF3N21Zd2plNFBreWFzUXxBQ3Jtc0trbHhhQnJNUlpCUFNraGNIN1VDOTJBOW93cmNhTGZlbmpsZzdlcV9GckJsWENXZ0x5MlBIMWFBYlpFNzFlV21PSjBPamEtNWdiWVRsczhPY3c4eU8yblJQV3A0SVNuOV9QVDFVcnNET2hxSlFCYTFLTQ&amp;q=https%3A%2F%2Fwww.cdc.gov%2Fvaccines%2Facip%2Fmeetings%2Fdownloads%2Fslides-2022-09-01%2F07-covid-swanson-508.pdf&amp;v=wTyNA5FzfQA\"> <span style=\"font-weight: 400;\">https:\/\/www.cdc.gov\/vaccines\/acip\/mee&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Pfizer and BioNTech Announce Omicron-Adapted COVID-19 Vaccine Candidates Demonstrate High Immune Response Against Omicron (BusinessWire) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbXV6NGhDam53aGhrOEF1bHI1aDlsNnBRa0xtUXxBQ3Jtc0trY0VETGp4RGxqakFUN19RRDZjU0E2akVCQVNxYUFfNE1SZVg0WmFTbzVVT1NXWHNLNGxwZnU4b2lGNmlGM2N5Q2ctaHZwODgzeTFhRWp4ZU1pbDBoV0JqdzdWVklzWnhxc2RHWkRuaHJvSTBpeXoxYw&amp;q=https%3A%2F%2Fwww.businesswire.com%2Fnews%2Fhome%2F20220625005002%2Fen%2FPfizer-and-BioNTech-Announce-Omicron-Adapted-COVID-19-Vaccine-Candidates-Demonstrate-High-Immune-Response-Against-Omicron&amp;v=wTyNA5FzfQA\"> <span style=\"font-weight: 400;\">https:\/\/www.businesswire.com\/news\/hom&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">A Bivalent Omicron-containing Booster Vaccine Against Covid-19 (medRxiv) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbXFJaWxxRTJjSnR6ZEZzQldYZi1KSGdoVzk0UXxBQ3Jtc0tsMXNtZjFQWHB6UDk0OWtEaEl1X3ZyMF9weUx6RTRVNUszVkVraVZESDdDX2NvMGZUNVJ1VGlxUndUR0lpRjduVXRzSERCWUFySWVwbjVJY3hvREZOSlFNZkFvM2lOdjQ3el9qU1VodXFqUGNxaGRqOA&amp;q=https%3A%2F%2Fwww.medrxiv.org%2Fcontent%2F10.1101%2F2022.06.24.22276703v1&amp;v=wTyNA5FzfQA\"> <span style=\"font-weight: 400;\">https:\/\/www.medrxiv.org\/content\/10.11&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Safety and immunogenicity of SARS-CoV-2 variant mRNA vaccine boosters in healthy adults: an interim analysis (Nature) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbGFrekdmT1dKMmZlNC1FS2Q0cEJtUDgwbnV2UXxBQ3Jtc0trZUhBNlRPWURjNzNpUnVFRVVLMW5WZ1FQUURSa1l0dnA4clAxS05EdDBLRUpIckJZTlNXY1F1bjNhbk5PdVJnc3JCNUZEZFJ4eFFBbUhxYzB5VjZvSlhiRWdyMktLajVLUzA0OFlwdGVNdkxhZkJOOA&amp;q=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41591-021-01527-y&amp;v=wTyNA5FzfQA\"> <span style=\"font-weight: 400;\">https:\/\/www.nature.com\/articles\/s4159&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant (bioRxiv) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbUp2blQzUFlGcGZucFhkaFU5UDE5UWNHV3h4QXxBQ3Jtc0tsc09lcVppRzdvdmxfaWM5N3l5elhObEVjeWpseGxaeVV2UDJhVk9WNGYtVzJyOWZOcV9GWE9qeFZLQ0dGc0RJUXRrbVNkRS1iM2FtNVlJcHI1LVN5NnZkQXczTGZVczcxS1hEVENoUmlNZ0VQMVZBRQ&amp;q=https%3A%2F%2Fwww.biorxiv.org%2Fcontent%2F10.1101%2F2022.09.12.507614v1&amp;v=wTyNA5FzfQA\"> <span style=\"font-weight: 400;\">https:\/\/www.biorxiv.org\/content\/10.11&#8230;<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant (NEJM) |<\/span><a href=\"https:\/\/www.youtube.com\/redirect?event=video_description&amp;redir_token=QUFFLUhqbjhXaDJ2Ym1mZGtaRkc2TU1UOVJoUWpiQ3JtZ3xBQ3Jtc0tsQjV1M0RNR3hMRnFjNGgwZ18xWmw0azdYMmFtMHBHNkNoclotb2d6YUlRTDlfRy1IUVdJYjB2RzlWUXRCbGlVT2JucV9vQVAyN2JrSnJYNElmWTdPMUhCTXFMU09sc21UVnozX0hyQjFmeUxNREJ6UQ&amp;q=https%3A%2F%2Fwww.nejm.org%2Fdoi%2F10.1056%2FNEJMoa2119451&amp;v=wTyNA5FzfQA\"> <span style=\"font-weight: 400;\">https:\/\/www.nejm.org\/doi\/10.1056\/NEJM&#8230;<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">All coronavirus updates are at MedCram.com (including more discussion on delta variant covid, COVID Delta, COVID children, natural immunity COVID 19, and more).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">MedCram Update 46:<\/span><a href=\"https:\/\/www.youtube.com\/watch?v=EFRwnhfWXxo&amp;t=0s\"> <span style=\"font-weight: 400;\">https:\/\/youtu.be\/EFRwnhfWXxo<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">MedCram Update 47:<\/span><a href=\"https:\/\/www.youtube.com\/watch?v=H1LHgyfPPQ8&amp;t=0s\"> <span style=\"font-weight: 400;\">https:\/\/youtu.be\/H1LHgyfPPQ8<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">MedCram Update 132:<\/span><a href=\"https:\/\/www.youtube.com\/watch?v=9OZZ6_M4OB0&amp;t=0s\"> <span style=\"font-weight: 400;\">https:\/\/youtu.be\/9OZZ6_M4OB0<\/span><\/a><\/p>\n<h2><b>Stay Tuned for More Updates\u00a0<\/b><\/h2>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Our COVID-19 videos are always available for <\/span><i><span style=\"font-weight: 400;\">free <\/span><\/i><span style=\"font-weight: 400;\">(and ad-free) at<\/span><a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\"> <span style=\"font-weight: 400;\">MedCram.com<\/span><\/a><span style=\"font-weight: 400;\">. In addition, check out our full library of courses and lectures on subjects ranging from<\/span> <a href=\"https:\/\/www.medcram.com\/courses\/hypertension-explained-clearly-2\"><span style=\"font-weight: 400;\">Hypertension Explained Clearly<\/span><\/a><span style=\"font-weight: 400;\"> to<\/span><a href=\"https:\/\/www.medcram.com\/courses\/sleep-apnea-explained-clearly\"> <span style=\"font-weight: 400;\">Sleep Apnea Explained Clearly<\/span><\/a><span style=\"font-weight: 400;\"> Course and many more!<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Meanwhile, you can find all of our COVID-19 videos compiled <\/span><a href=\"https:\/\/www.medcram.com\/collections?category=covid-19-SARS-CoV-2\"><span style=\"font-weight: 400;\">here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Visit <\/span><a href=\"https:\/\/www.medcram.com\/\"><span style=\"font-weight: 400;\">MedCram.com<\/span><\/a><span style=\"font-weight: 400;\"> for updates on Monkeypox virus infectious disease and more.<\/span><\/p>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; In this video, Roger Seheult, MD of MedCram discusses the new bivalent boosters that are currently being offered. These new boosters are called bivalent because they have 2 different mRNAs to code for two different spike proteins because Omicron is so different from the original Wuhan strain of SARS-CoV-2. Whether you should get&hellip;<!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":8,"featured_media":1358,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Omicron booster clearly explained - Medcram Blog<\/title>\n<meta name=\"description\" content=\"In this video, Roger Seheult, MD of MedCram discusses the new bivalent boosters that are currently being offered.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.medcram.com\/covid-19\/new-bivalent-boosters\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Omicron booster clearly explained - 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