{"id":626,"date":"2019-11-26T10:03:47","date_gmt":"2019-11-26T17:03:47","guid":{"rendered":"https:\/\/blog.medcram.com\/?p=626"},"modified":"2019-11-26T10:05:51","modified_gmt":"2019-11-26T17:05:51","slug":"the-latest-on-vitamin-c-in-sepsis-treatment","status":"publish","type":"post","link":"https:\/\/blog.medcram.com\/critical-care\/the-latest-on-vitamin-c-in-sepsis-treatment\/","title":{"rendered":"The Latest on Vitamin C in Sepsis Treatment"},"content":{"rendered":"<p style=\"text-align: center;\"><iframe loading=\"lazy\" src=\"https:\/\/www.youtube.com\/embed\/lYGoaW1gKQw\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Following up on Dr. Seheult\u2019s lecture, <\/span><a href=\"https:\/\/youtu.be\/RA7obbfGg_o\"><i><span style=\"font-weight: 400;\">Vasopressors and Vitamin C in Sepsis Explained Clearly<\/span><\/i><\/a><span style=\"font-weight: 400;\">, we\u2019ve got new information on the controversy of vitamin C in sepsis treatment.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><b>The Marik Protocol and Resulting Controversy<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">In our <\/span><a href=\"https:\/\/youtu.be\/RA7obbfGg_o\"><span style=\"font-weight: 400;\">previous video<\/span><\/a><span style=\"font-weight: 400;\">, as well as our series on <\/span><a href=\"https:\/\/www.medcram.com\/courses\/vasopressors-inotropes\"><span style=\"font-weight: 400;\">vasopressors<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.medcram.com\/courses\/shock-and-sepsis-explained-clearly\"><span style=\"font-weight: 400;\">shock and sepsis<\/span><\/a><span style=\"font-weight: 400;\">, Dr. Seheult described the polarizing study by Paul Marik, which looked at the use of vitamin C to treat sepsis. The study employed Marik\u2019s protocol of vitamin C, hydrocortisone, and thiamine, and although it decreased mortality from 40.4 to 8.5 percent, it also drew loads of criticism for not being a randomized, placebo-controlled trial.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><b>What We Know Now About Vitamin C and Sepsis Treatment<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Since the Marik study, a randomized controlled trial (RCT) was released, called the <\/span><a href=\"https:\/\/emcrit.org\/pulmcrit\/pulmcrit-citris-ali-can-a-secondary-endpoint-stage-a-coup-detat\/\"><span style=\"font-weight: 400;\">CITRIS-ALI trial<\/span><\/a><span style=\"font-weight: 400;\">, in The Journal of the American Medical Association (JAMA). This new study looked at a larger number of patients who were given either a placebo or vitamin C not just during septic shock, but also after the onset of ARDS, or acute respiratory distress syndrome.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In sum, this study was intended to study ARDS and not just sepsis, so the interpretation of the results gets a little tricky. Patients given vitamin C did experience a significant drop in mortality, however, the CITRIS-ALI trial was not designed to look at mortality as a primary endpoint\u2026 and so the debate over vitamin C\u2019s efficacy in treating septic shock ensues.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><b>The Full MedCram Update on Vitamin C and Septic Shock<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">For the full interpretation and explanation of the CITRIS-ALI trial and the updated picture on using vitamin C for sepsis, check out our video, <\/span><a href=\"https:\/\/youtu.be\/lYGoaW1gKQw\"><i><span style=\"font-weight: 400;\">Sepsis Treatment &amp; Vitamin C &#8211; Trials &amp; Updates (Septic Shock)<\/span><\/i><\/a><span style=\"font-weight: 400;\"> now. Keep following along, as we anticipate more information on this topic to be released soon!<\/span><\/p>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>&nbsp; Following up on Dr. Seheult\u2019s lecture, Vasopressors and Vitamin C in Sepsis Explained Clearly, we\u2019ve got new information on the controversy of vitamin C in sepsis treatment. &nbsp; The Marik Protocol and Resulting Controversy In our previous video, as well as our series on vasopressors and shock and sepsis, Dr. Seheult described the polarizing&hellip;<!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":5,"featured_media":629,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Latest on Vitamin C in Sepsis Treatment - Medcram Blog<\/title>\n<meta name=\"description\" content=\"Check out the newest MedCram video on the possible benefits and controversy of utilizing vitamin C in sepsis treatment. 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This video follows up Dr. Seheult&#039;s previous talk on septic shock, vasopressors, and vitamin C.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blog.medcram.com\/critical-care\/the-latest-on-vitamin-c-in-sepsis-treatment\/\" \/>\n<meta property=\"og:site_name\" content=\"Medcram Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/MedCram\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-26T17:03:47+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-11-26T17:05:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blog.medcram.com\/wp-content\/uploads\/2019\/11\/Screen-Shot-2019-11-26-at-8.53.26-AM.png\" \/>\n\t<meta property=\"og:image:width\" content=\"698\" \/>\n\t<meta property=\"og:image:height\" content=\"388\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Taylor Goodin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@medcramvideos\" \/>\n<meta name=\"twitter:site\" content=\"@medcramvideos\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Taylor Goodin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/blog.medcram.com\/critical-care\/the-latest-on-vitamin-c-in-sepsis-treatment\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/blog.medcram.com\/critical-care\/the-latest-on-vitamin-c-in-sepsis-treatment\/\"},\"author\":{\"name\":\"Taylor Goodin\",\"@id\":\"https:\/\/blog.medcram.com\/#\/schema\/person\/c2ff78c8619fbb1ba2c1b15e0c098da5\"},\"headline\":\"The Latest on Vitamin C in Sepsis Treatment\",\"datePublished\":\"2019-11-26T17:03:47+00:00\",\"dateModified\":\"2019-11-26T17:05:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/blog.medcram.com\/critical-care\/the-latest-on-vitamin-c-in-sepsis-treatment\/\"},\"wordCount\":309,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/blog.medcram.com\/#organization\"},\"articleSection\":[\"Critical Care\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/blog.medcram.com\/critical-care\/the-latest-on-vitamin-c-in-sepsis-treatment\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/blog.medcram.com\/critical-care\/the-latest-on-vitamin-c-in-sepsis-treatment\/\",\"url\":\"https:\/\/blog.medcram.com\/critical-care\/the-latest-on-vitamin-c-in-sepsis-treatment\/\",\"name\":\"The Latest on Vitamin C in Sepsis Treatment - Medcram Blog\",\"isPartOf\":{\"@id\":\"https:\/\/blog.medcram.com\/#website\"},\"datePublished\":\"2019-11-26T17:03:47+00:00\",\"dateModified\":\"2019-11-26T17:05:51+00:00\",\"description\":\"Check out the newest MedCram video on the possible benefits and controversy of utilizing vitamin C in sepsis treatment. 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